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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
REPORTS of the Scientific Committee on Cosmetology (seventh series)
Author:
European Commission (EC) - Scientific Committee on Cosmetology (SCC)
Year:
1988
Bibliographic source:
COMMISSION OF THE EUROPEAN COMMUNITIES; Brussels, Luxembourg, 1988.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An ocular irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on rabbits to assess the eye irritancy of test chemical.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(4-methyl-2-nitrophenylazo)-2-naphthol
EC Number:
219-372-2
EC Name:
1-(4-methyl-2-nitrophenylazo)-2-naphthol
Cas Number:
2425-85-6
Molecular formula:
C17H13N3O3
IUPAC Name:
1-(4-Methyl-2-nitrophenylazo)-2-naphthol
Test material form:
solid
Details on test material:
- Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+
Specific details on test material used for the study:
- Name of test material: C.I. Pigment Red 3
- Molecular formula: C17H13N3O3
- Molecular weight: 307.308 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(\N=N\c3c(cc(C)cc3)[N+](=O)[O-])c(ccc1cccc2)O
- InChI: 1S/C17H13N3O3/c1-11-6-8-14(15(10-11)20(22)23)18-19-17-13-5-3-2-4-12(13)7-9-16(17)21/h2-10,21H,1H3/b19-18+

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No Data Available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Amount : 100mg
concentration applied: 100%
Duration of treatment / exposure:
No Data Available
Observation period (in vivo):
No Data Available
Duration of post- treatment incubation (in vitro):
No Data Available
Number of animals or in vitro replicates:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
fully reversible
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Slight conjunctival changes only after one hour.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material C.I. Pigment Red 3(CAS No: 2425-85-6) was considered to be not irritating to rabbits’ eye.
Executive summary:

An ocular irritation study of chemical C.I. Pigment Red 3(CAS No: 2425-85-6) was conducted on rabbits to assess the eye irritancy of test chemical.

 

The undiluted 100mg ofC.I. Pigment Red 3 was installed into the eye of each rabbits which produced Slight conjunctival changes only after one hour.

 

Since the observed effects were cleared, the chemical C.I. Pigment Red 3(CAS No: 2425-85-6)was considered to be not irritating to therabbits’ eye.