Phosphorus tribromide

Endpoint summary

Description of key information

Acute oral toxicity:

LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary source

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity study of phosphorus (3+) tribromide in rats

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

- Name of test material : Phosphorus tribromide (phosphorus (3+) tribromide)
- Molecular formula: Br3P
- Molecular weight : 270.686 g/mole
- Smiles notation :P(Br)(Br)Br
- InChl :1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Solid

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

not specified

Doses:

50,400 and 3200 mg/kg bw

No. of animals per sex per dose:

3

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs and body weight were examined.

Statistics:

not specified

Preliminary study:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

< 50 mg/kg bw

Based on:

test mat.

Remarks on result:

other: More than 50 % mortality was observed

Mortality:

More than 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing

Clinical signs:

other: Weakness, prostration (wet around mouth, difficult breathing) were observed.

Gross pathology:

not specified

Other findings:

not specified

Interpretation of results:

Category 2 based on GHS criteria

Conclusions:

LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.

Executive summary:

In a acute oral toxicity study, rat were treated with phosphorus (3+) tribromide in the concentration of 50,400 and 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing. Weakness, prostration (wet around mouth, difficult breathing) were observed. Therefore,LD50 was considered to be< 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

50 mg/kg bw

Quality of whole database:

Data is klimiach 4 and from secondary source

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute oral toxicity:

In different studies, phosphorus (3+) tribromide has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rats for phosphorus (3+) tribromide along with the study available on structurally similar read across substance phosphorus (3+) trichloride (CAS no 7719-12-2). 

In a experimental study conducted by Eastman Kodak Co (OTS0555394, Eastman Kodak Company, 1992), rat were treated with phosphorus (3+) tribromide in the concentration of 50,400 and 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing. Weakness, prostration (wet around mouth, difficult breathing) were observed. Therefore, LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.

In another experimental study given by U.S. National Library of Medicine (ChemIDplusA TOXNET DATABASE, 2017) and German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States, 2017) on structurally similar read across substance phosphorus (3+) trichloride (CAS no 7719-12-2), rat were treated with phosphorus (3+) trichloride in the concentration of18 mg/kg bw orally. 50 % mortality was observed in treated rats at 18 mg/kg bw. Therefore, LD50 was considered to be18 mg/kg bw when rat were treated with phosphorus (3+) trichloride orally.

Thus, based on the above study on phosphorus (3+) tribromide and its read across substances, it can be concluded that LD50 value is less than 50 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, phosphorus (3+) tribromideacetate can be classified as Category II of acute oral toxicity.

 

Justification for classification or non-classification

Based on the above study on phosphorus (3+) tribromide and its read across substances, it can be concluded that LD50 value is less than 50 mg/kg bw for oral and less than 1.0 mg/L Thus, comparing this value with the criteria of CLP regulation, phosphorus (3+) tribromideacetate can be classified as Category II of acute oral toxicity.