Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 613-701-7 | CAS number: 6485-45-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats
- Author:
- Yamamoto K et al.
- Year:
- 1 995
- Bibliographic source:
- Carcinogenesis 16 (11): 2633-2636.
Materials and methods
- Type of study / information:
- liver foci test
- Principles of method if other than guideline:
- see details in remarks on material and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): 2,6-dimethylmorpholine
Constituent 1
Results and discussion
Any other information on results incl. tables
| Treatment | No. of rats | No of foci (per cm2) | No of foci (per cm3) |
percent of area occupied by foci (%) | ||
| 0.25% DMM | 8 | 1±1 | 11±9 | 0.2±0.2 | ||
| 0.25% DMM + 0.3% NaNO2 | 10 | 32±8 | 389±106 | 14.7±9.2 |
Number of foci per cm2 were significantly increased in the group given 2,6-dimethylmorpholine together with nitrite compared to values for groups given test article or nitrite alone. Further, the numbers of lesions were essentially similar to those found in rats given carcinogenic doses of Nitroso-dimethylmorpholine. The results clearly demonstrate hepatocyte initiation activities of endogenously formed carcinogens.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
