Registration Dossier
Registration Dossier
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EC number: 212-028-2 | CAS number: 751-83-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
IN VITRO
In a reverse gene mutation assay in bacteria (BASF, 1998), strains TA 1535, TA 1537, TA 98 and TA 100 of S. typhimurium and WP2 uvrA of E. coli were exposed to C15-Salz (purity 90% (w/w), no further data) in DMSO at concentrations of 0.3 – 5000 µg/plate (Standard Plate Test) and 0.3 – 6 µg/plate (Preincubation Test) in the presence and absence of mammalian metabolic activation.
C15-Salz was tested up to limit concentration (5000 µg/plate) in the Standard Plate Test and up to cytotoxic concentration in the Preincubation Test. Bacteriotoxicity was noted at concentrations from 0.75 µg/plate onwards, depending on the tester strain and test conditions. No precipitation of the test substance was observed at any concentration tested.
The positive controls induced the appropriate responses in the corresponding strains. There was no evidence of induced mutant colonies over background.
This study is classified as acceptable. This study satisfies the requirement for Test Guideline OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation) data.
IN VIVO
No data are available.
Short description of key information:
IN VITRO
There was no evidence of reverse gene mutation in bacteria.
IN VIVO
No data are available.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
There is no need to classify C15-Salz for mutagenicity according to the Directive 67/548/EC or GHS criteria.
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