Registration Dossier
Registration Dossier
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EC number: 216-467-0 | CAS number: 1591-02-2
Endpoint summary
Administrative data
Description of key information
The key study for acute oral toxicity reports an LD50 of >2000 mg/kg bw for rats in a study conducted according OECD TG 423 and in compliance with GLP (BSL Bioservice, 2015a).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study for acute oral toxicity reports an LD50 of >2000 mg/kg bw for rats in a study conducted according OECD TG 423 and in compliance with GLP (BSL Bioservice, 2015a). There were no mortalities. The clinical signs were minimal, and were reported to include slight to moderate piloerection, and slightly reduced spontaneous activity. There was no effect on body weight gain. There were no specific findings at necropsy.
Justification for selection of acute toxicity – oral endpoint
The study was conducted according to current OECD guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available data, no classification is required for acute toxicity in accordance with Regulation (EC) No. 1272/2008.
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