Registration Dossier
Registration Dossier
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EC number: 603-330-9 | CAS number: 129332-29-2
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 March 2002- 07 March 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 00945
- IUPAC Name:
- 00945
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
Results and discussion
- Preliminary study:
- At pH 4, pH 7 and pH 9, a decrease in concentration >10% was observed after 5 days(half-life time at 25 degrees celsius <1 year). In order to determine if hydrolysis of the test substance is a pseudo-first order reaction and to determine the half life time at 25 degrees, subsequent tests should be performed at these pH values. For these tests accurate determination of concentration is required. Because, based on the preliminary test, areas are very low, this is not possible using the analytical method developed during NOTOX project 337163.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on preliminary tests, concentrations are expected to be below 0.03mg/L and therefore, it is not possible to determine the hydrolysis of the tessubstance as a function of pH.
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