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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Performed to recognised methods 2014

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
Principles of method if other than guideline:
Sighting study performed with 300 mg/kg and 2000 mg/kg
GLP compliance:
yes (incl. QA statement)
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Reference substance name:
(2-aminoethyl)(2-{[(2E)-3-methoxy-2-methyl-3-(octylsulfanyl)prop-2-en-1-yl]amino}ethyl)amine; 11-methoxy-12-methyl-3-(prop-1-en-2-yl)-2-oxa-4,7,10,14,17-pentaazanonadecan-19-amine; 2-methyl-3-(octylsulfanyl)-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; 3-({2-[(2-aminoethyl)amino]ethyl}amino)-2-methyl-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; N-{2-[(2-aminoethyl)amino]ethyl}-2-methyl-3-(octylsulfanyl)propanamide
EC Number:
929-305-5
IUPAC Name:
(2-aminoethyl)(2-{[(2E)-3-methoxy-2-methyl-3-(octylsulfanyl)prop-2-en-1-yl]amino}ethyl)amine; 11-methoxy-12-methyl-3-(prop-1-en-2-yl)-2-oxa-4,7,10,14,17-pentaazanonadecan-19-amine; 2-methyl-3-(octylsulfanyl)-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; 3-({2-[(2-aminoethyl)amino]ethyl}amino)-2-methyl-N-{2-[(2-{2-[(octylsulfanyl)methyl]propanamido}ethyl)amino]ethyl}propanamide; N-{2-[(2-aminoethyl)amino]ethyl}-2-methyl-3-(octylsulfanyl)propanamide
Test material form:
other: Liquid
Details on test material:
Identification: Reaction product of n-octylmercaptan, methyl methacrylate (MMA) and diethylenetriamine (DETA)
Physical state / Appearance: amber viscous liquid
Purity: >99%

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
Sighting study of 300 and 2000 mg/kg; no effects
Main study 2000 mg/kg
No. of animals per sex per dose:
1 Female at 300 mg/kg sighting study
1 Female at 2000 mg/kg in sighting study
4 further females at 2000 mg/kg in study
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
discriminating dose
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: None
Gross pathology:
None
Other findings:
None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The discriminating dose was considered > 2000 mg/kg
Executive summary:

No adverse effects at 2000 mg/kg.

Note that this animal test was initially performed to meet non-EU regulatory demands.