Registration Dossier
Registration Dossier
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EC number: 619-738-5 | CAS number: 87305-03-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 December 2001 to 25 Februar 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- yes
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- (1R,4R,5S)-6,6-dimethyl-4-(tribromomethyl)-3-oxabicyclo[3.1.0]hexan-2-one
- Cas Number:
- 87305-03-1
- Molecular formula:
- C8H9Br3O2
- IUPAC Name:
- (1R,4R,5S)-6,6-dimethyl-4-(tribromomethyl)-3-oxabicyclo[3.1.0]hexan-2-one
- Details on test material:
- Chinese Hamster Ovary (CHO) cells
Constituent 1
Method
- Test concentrations with justification for top dose:
- Concentration range in the main test (ug/ml)
With metabolic activation: Lower Upper Without metabolic activation: Lower Upper
60 480 60 480
30 400 30 400
- Vehicle / solvent:
- DMSO
Results and discussion
Any other information on results incl. tables
Concentration producing toxicity
a) In a preliminary test - with metabolic activation: > 471.25 ug/ml
- Without metabolic activation: > 471.25 ug/ml
b) In the main test - with metabolic activation: > 320 ug/ml
- Without metabolic activation: > 240 ug/ml
Applicant's summary and conclusion
- Conclusions:
- Haloester is not mutagenic
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