6-aminopenicillanic acid

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-10-20 to 2010-02-05

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: A GLP study conducted to current accepted guidelines.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

With the exception of the Boiling Temperature calculation, the work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).

Type of method:

differential scanning calorimetry

Remarks:

(DSC)

Boiling pt.:

699 K

Atm. press.:

99.36 kPa

Decomposition:

yes

Decomp. temp.:

>= 435 K

Table 2: Thermographic Data – Determination 1

Thermal Event		Interpretation		Temperature
			ºC		K
Exotherm		Onset of decomposition		161.77		435
		Peak decomposition		210.52		484

Atmospheric pressure: 99.36 kPa

 

Table 3: Thermographic Data – Determination 2

Thermal Event	Interpretation	Temperature
		ºC	K
Exotherm	Onset of decomposition	164.74	438
	Peak decomposition	210.28	483

Atmospheric pressure: 99.36 kPa

Overall result: decomposition from approximately 435 K

 

As the test material decomposed, no value for the boiling temperature could be determined experimentally. However, using an adaptation of the Stein and Brown method, MPBPWIN version 1.43, ©2000 US Environmental Protection Agency, the boiling temperature was calculated to be 699 K.

Conclusions:

The test material has been determined to decompose from approximately 435 K at 99.36 kPa. As the test material decomposed, no value for boiling temperature could be determined. A calculated value of boiling temperature gave a result of 699 K.

Description of key information

The boiling point of 6-Aminopenicillanic acid was calculated by the EU method A2 and the an adaptation of the Stein and Brown Method MPBPWIN version 1.43, ©2000 US Environmental Protection Agency in the report by Fox and White 2010.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

699 K

Additional information

The atmospheric pressure was recorded at 99.6 kPa