Registration Dossier
Registration Dossier
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EC number: 203-585-2 | CAS number: 108-46-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo insect germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study; No data regarding GLP
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Principles of method if other than guideline:
- Method: other: Zimmering et al (1985)
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- other: Canton-s wild type
- Sex:
- male
Administration / exposure
- Route of administration:
- other: feed (diet)
- Duration of treatment / exposure:
- 72 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
11,000 ppm
Basis:
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- Lethality measured as part of the test protocol
Any other information on results incl. tables
Resorcinol (11,000 ppm) was negative for induction of sex-linked recessive lethal mutations in germ cells of male Drosophila melangaster when administered to adult flies by feeding.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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