Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2000
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed data collection from international group of experts.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Concise International Chemical Assessment Document 20; Mononitrophenols; 8.1 Single exposure
Author:
Fraunhofer Institute for Toxicology and Aerosol Research
Year:
2000
Bibliographic source:
International Programme on Chemical Safety (IPCS), ISBN 92 4 153020 0

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not applicable; The guidelines used for conduction of the studies are not stated in CICAD.
Deviations:
not applicable
Principles of method if other than guideline:
Not applicable; summary of peer-reviewed data
GLP compliance:
not specified
Test type:
other: not applicable; summary of peer-reviewed data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitrophenol
EC Number:
202-811-7
EC Name:
4-nitrophenol
Cas Number:
100-02-7
Molecular formula:
C6H5NO3
IUPAC Name:
4-nitrophenol
Details on test material:
- Name of test material (as cited in study report): 4-nitrophenol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
Not applicable; the dose ranges applied to the animals in the different investigations is not stated in the CICAD.
No. of animals per sex per dose:
Not applicable; the number of animals used per dose group in the different investigations is not stated in the CICAD.
Control animals:
not specified
Statistics:
Not applicable

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
220 - 620 mg/kg bw
Mortality:
Not applicable
Clinical signs:
other: Unspecific clinical signs including trachypnoea and cramps
Gross pathology:
Macroscopic examination revealed a greyish discolouration with dark red patches of the lungs.
Other findings:
The LD50 is cited to be in the range of 380-470 mg/kg bw in mice.

Any other information on results incl. tables

No other information.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 after oral administration of 4-nitrophenol is cited to be in the range of 220 - 620 mg/kg bw in rats and 380 - 470 mg/kg bw in mice.
Executive summary:

In the Concise International Chemical Assessment Document on Mononitrophenols (2 -nitrophenol and 4 -nitrophenol) the LD50 values after single oral administration of 4 -nitrophenol are cited to be in the range of 220 - 620 mg/kg bw in rats and 380 - 470 mg/kg bw in mice.