Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-811-7 | CAS number: 100-02-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The long-term toxicity of 4-Nitrophenol to fish species has been extensively reviewed by international groups of experts, i.e. BUA report No.75 (1992), IPCS CICAD (2000), ECB IUCLID (2000) and the US EPA under the HPV Chemicals Challenge Program (2004). In a long-term exposure of a marine fish species (sheepshead minnow, Cyprinodon variegatus) from the egg-stage to 28 days after hatching, 16 mg 4 -Nitrophenol/L in the flow-through system resulted in a reduction in the hatching rate to 2 % ( control 89%) and led to the death of all hatched young. No effects could be determined below 16 mg/L (Ward et al. 1981, cited from the BUA report 1992). After prolonged exposure of zebra fish to 4 -Nitrophenol, minor morphological iterations of the liver, even at a concentration of 0.1 mg/L, were observed. At 1 and 5 mg/L, about 25% of animals showed symptoms of degenerative transformation of the liver tissue into large , polynuclear cell masses (Braunbeck et al. 1989, cited from IPCS CICAD 2000).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
