2-ethylhexyl mercaptoacetate

Repeated dose toxicity: dermal

Administrative data

Endpoint:

short-term repeated dose toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: This study was performed according to generally accepted scientific standards, but it suffers severe limitations.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1974

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Repeated dermal application of substance on rat skin for 10 days.
Only one very low concentration was tested.
No data on environmental conditions.
The parameters examined were limited and results were not detailed.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl mercaptoacetate

EC Number:

231-626-4

EC Name:

2-ethylhexyl mercaptoacetate

Cas Number:

7659-86-1

Molecular formula:

C10H20O2S

IUPAC Name:

2-ethylhexyl 2-sulfanylacetate

Details on test material:

- Name of test material (as cited in study report): Thioglykolsäure-2-äthylhexylester
- Analytical purity: technical quality
- Impurities (identity and concentrations): no relevant impurity

Test animals

Species:

rat

Strain:

other: conventional random strain of the "Staatlichen Zentralstelle für versuchstierzucht und-versorgung, Berlin-Lichtenberg

Sex:

female

Administration / exposure

Type of coverage:

not specified

Vehicle:

ethanol

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

2 weeks

Frequency of treatment:

5 day/week

Doses / concentrations

Remarks:

Doses / Concentrations:
3 mL/kg of a 20% solution in ethanol
Basis:
nominal per unit body weight

No. of animals per sex per dose:

10 animal (including both sexes)

Control animals:

yes

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

No local reaction was observed. Body weight gain was not affected in the animals, but 3 of
the 10 rats died on day 11. At the end of exposure period, necropsy was performed on surviving animals. No macroscopically visible
damage to the organs was evidenced.
Results of mortality for control group were not reported. 

Applicant's summary and conclusion

Conclusions:

In this study, animals were exposed dermally for 10 days to the substance applied in 20% solution in ethanol at 3 mL/kg, corresponding approximately to 0.58 mg/kg bw. No significant treatment-related effects were observed on bodyweight gain, or on organs macroscopically examined at necropsy, but 3/10 rats died on day 11.

Executive summary:

To study the subacute dermal toxicity of thioglycolic acid
2-ethylhexyl ester, 3 ml of a 20% ethanolic solution/kg body
weight (correponding approximately to 0.58 mg/kg) was applied to the clipped dorsal skin of 10 female
rats as a single dose daily for 2 weeks (10 exposures).

No local reaction was observed. Body weight gain was not affected in the animals, but 3 of
the 10 rats died on day 11. 

    

At the end of exposure period, necropsy was performed on surviving animals. No macroscopically visible
damage to the organs was evidenced.