2-ethylhexyl mercaptoacetate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Not sufficiently detailed study suffering severe limitations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1947

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

In this old study (study conducted largely before the date of publication of the OECD Guidelines relevant for this endpoint), animals were exposed intraperitoneally to test substance at 6 different concentrations and were only observed for mortality.
When compared to standard acute toxicity studies, this study suffers various limitations: only males were dosed; the observation period was only 7 days; the protocol was poorly described; the equipment used was not detailed; the analytical monitoring was not performed and animals were only observed for determinig the mortality rate.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl mercaptoacetate

EC Number:

231-626-4

EC Name:

2-ethylhexyl mercaptoacetate

Cas Number:

7659-86-1

Molecular formula:

C10H20O2S

IUPAC Name:

2-ethylhexyl 2-sulfanylacetate

Details on test material:

- Name of test material (as cited in study report):
Thioglycolate de 2-ethyle hexyle

Test animals

Species:

mouse

Strain:

Swiss

Sex:

male

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

arachis oil

Doses:

0.8, 1.0, 1.2, 1.4, 1.5, 1.6 mL/kg (corresponding to approximately 0.78, 0.97, 1.17, 1.36, 1.46, 1.56 g/kg bw based on a reported density of 0.972
g/mL)

No. of animals per sex per dose:

10 animals in 0.8-, 1.0- and 1.6-mL/kg treatment groups; 20 animals in the other treatment groups.

Control animals:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

1.36 mL/kg bw

95% CL:

1.33 - 1.39

Remarks on result:

other: LD50 equivalent to 1320 mg/kg bw

Any other information on results incl. tables

Table of mortality

Tested concentration (mL/kg)	Mortality
	Number of animals	Rate (%)
0.8	0/10	0
1.0	0/10	0
1.2	3/20	15
1.4	10/20	50
1.5	15/20	70
1.6	10/10	100

Applicant's summary and conclusion

Conclusions:

By intraperitoneal administration, the LD50 was estimated to be 1320 mg/kg bw in mouse.

Executive summary:

In this old study, groups of 10 to 20 male swiss mice were given the substance at 0.8 to 1.6 mL/kg by intraperitoneal injection. The LD50 was found to be 1.36 ml/kg bw, equivalent to 1320 mg/kg bw, based on the density of the substance of 0.972 mL/g.