[2-(2-methoxymethylethoxy)methylethoxy]propanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted prior to GLP and guidelines. The report contains sufficient amount of data for the interpretation of the results. Non-GLP study equivalent to OECD guideline 403.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

[2-(2-methoxymethylethoxy)methylethoxy]propanol

EC Number:

247-045-4

EC Name:

[2-(2-methoxymethylethoxy)methylethoxy]propanol

Cas Number:

25498-49-1

Molecular formula:

C10H22O4

IUPAC Name:

[2-(2-Methoxymethylethoxy)methylethoxy]propanol

Details on test material:

ropasol Solvent TM
Amount Received: 1 pint
Sample No. 40-130
ID: 511-01-1485
Receipt Date: March 22, 1977

Test animals

Species:

rat

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:Glass Exposure chamber
- Exposure chamber volume: 9 litre
- Source and rate of air:Substantially saturatted vapor
- Method of particle size determination: Dynamically
- Temperature, humidity, pressure in air chamber: 24C

Duration of exposure:

8 h

Concentrations:

30 ppm at 25C

No. of animals per sex per dose:

6

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

> 30 ppm

Exp. duration:

8 h

Remarks on result:

other: No signs of toxicity observed

Mortality:

No

Clinical signs:

other: No

Body weight:

Increase i.e., 53 to 77 grams

Gross pathology:

Nothing remarkable

Other findings:

No

Any other information on results incl. tables

Procedure A	Time	Concentration	Dead/Dosed	Death	Weight Change	Signs and/or symptoms
A	8 hr	Substantially saturated vapor	0/6	-	53 to 77 gm	-

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

No hazard is anticipated from the infrequent inhalation of substantially saturated vapor generated at room temperature under normal handling conditions.

Executive summary:

Six rats were exposed to concentrated vapors for 8 hours. Concentrated vapor was generated in a gas washing bottle by passing dried air at 2.5 liters/min through a fritted glass disc immersed to a depth of at least 1 -1/2 inches in the chemical which is delivered to rats in a 9 -liter glass exposure chamber. Mean vapor concentration was calculated from the loss in weight of the liquid or estimated from the vapor pressure at the acutal temperature of the chemical during aeration.

No signs/symptoms of toxicity observed during the observation. Gross pathology shows no remarkable changes in it. There was a gradual increase inthe body weight range observed in all the rats. Out of six rats, all animals servived without any changes. No hazard is anticipated from the infrequent inhalation of substantially saturated vapor generated at room temperature under normal handling conditions.