Registration Dossier
Registration Dossier
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EC number: 904-304-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Crude 1,3-dichloropropene was evaluated for eye and skin irritation potential with in vitro O.E.C.D. Testing Guideline studies conducted with GLP compliance.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Crude 1,3 -dichloropropene was found to be a skin irritant based on the outcome of Draft O.E.C.D. Testing Guideline "In Vitro Skin Irritation" study conducted with the human keratinocyte EPISKIN tissue model. The Relative Permeability reported in this study for Crude 1,3 -dichloropropene was 8.4 ± 1.3%. In an O.E.C.D. Testing Guideline No. 437, " Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants" Crude 1,3 -dichloropropene was not reported to be an eye irritant with a mean In Vitro Irritancy Score (IVIS) of 43.2 ± 9.9.
Effects on skin irritation/corrosion: irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the outcome of an in vitro skin irritation O.E.C.D. Testing Guideline study Crude 1,3 -dichloropropene requires Classification and Labeling as R38, "Irritating to Skin". The data from an in vitro O.E.C.D. Testing Guideline No. 437 study do not support the Classification and Labeling of 1,3 -dichloropropene as an eye irritant.
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