Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Tributyl phosphate is a non volatile liquid substance with low water solubility and low vapour pressure.
Experimental data obtained via oral exposure route better describes systemic toxicity of tributyl phosphate. Overall, it is considered thatthe available experimental data is adequate, relevant and reliable to perform the safety assessment for this substance.
The following systemic toxicity values for tributyl phosphate were observed in studies in rodents:
Chronic:
· NOEL (mice, 18 months, systemic toxicity effects, including carcinogenicity) =24.1 mg/kg bw/day (males) and 28.9 mg/kg bw/day (females).
· LOAEL (rats, 2 year, carcinogenicity) =143 mg/kg bw/day (male).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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