Registration Dossier
Registration Dossier
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EC number: 204-800-2 | CAS number: 126-73-8
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: US EPA accepted QSAR method for organic chemicals properties assessment.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- BCFBAF
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
Test material
- Reference substance name:
- Tributyl phosphate
- EC Number:
- 204-800-2
- EC Name:
- Tributyl phosphate
- Cas Number:
- 126-73-8
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- tributyl phosphate
Constituent 1
Results and discussion
Any other information on results incl. tables
Overview of studies on aquatic bioaccumulation of tributyl phosphate
Method
|
Results |
Remarks |
Reference |
QSAR estimate BCFBAF v.3.00 |
Log BCF =1.48; BCF =30.3 L/kg wet wt (regression-based estimate)
Biotransformation half-life =0.289 days (normalized to 10 g fish)
Log BAF =1.84 BAF =69.7 L/kg wet-wt (Arnot-Gobas upper trophic) |
2 (reliable with restrictions)
key study
(Q)SAR |
USEPA (EPI Suite v.4.00) |
CAESAR QSAR model for bioconcentration factor (BCF) in fish |
BCF value: 37 (L/Kg) whole body weight
Log BCF value: 1.57
(Appendix 2) |
2 (reliable with restrictions)
key study
(Q)SAR |
CAESAR QSAR model for bioconcentration factor (BCF) in fish |
Applicant's summary and conclusion
- Conclusions:
- Generally, a BCF/BAF in fish of ≥ 500 is indicative of the potential to bioconcentrate for classification purposes in accordance with CLP/GHS criteria. The BCF/BAF values estimated for tributyl phosphate are well below the cut-off values for bioaccumulation. Therefore, tributyl phosphate is not likely to bioaccumulate in aquatic organisms.
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