Registration Dossier
Registration Dossier
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EC number: 249-277-1 | CAS number: 28874-51-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Growth rate: 72 hour NOEC 25 mg/L, LOEC 50 mg/L; Yield: 72 hour NOEC 12.5 mg/L, LOEC 25 mg/L, OECd 201, EU Method C.3, EPA OPPTS 850.5400, Sipos (2013b).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 25 mg/L
Additional information
In the key study (Sipos, 2013b) the toxicity of the test material to algae was determined in a growth inhibition study performed under GLP conditions and in line with standardised guidelines. The study was assigned a reliability score of 1 in accordance with the principles for assessing data quality as defined in Klimisch (1997).
Pseudokirchnerella subcapitata were exposed to the test material at nominal concentrations of 6.25, 12.5, 25, 50 and 100 mg/L for 72 hours under freshwater static conditions. Analytical verification of the test concentrations showed that the test material absorbed to the increasing algal biomass. Therefore effect concentrations have been reported in terms of nominal concentrations.
Under the conditions of the test, significant inhibition of algal growth was observed at concentrations ≥ 50 mg/L. Therefore the NOEC was determined as 25 mg/L and LOEC was determined as 50 mg/L. At the highest concentration tested 22.3% growth rate inhibition was observed, the EC50 was therefore considered to be greater than 100 mg/L.
The 0-72 h areas and yield were significantly different from that of the control group in the examined concentration range of 25 - 100 mg/L (nominal), therefore the NOEC was determined as 12.5 mg/L and LOEC was determined as 25 mg/L (nominal).
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