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EC number: 264-140-6
CAS number: 63429-28-7
an acute oral toxicity study performed according to OECD Guideline 420
and in compliance with GLP, groups (5 females/dose) of Wistar
(RccHan™:WIST) rats were given a single oral (gavage) dose of test
material at 2000 mg/kg bw. Animals were then observed for mortality,
clinical signs and bodyweights for 14 days and at the end of the study
the surviving animals were sacrificed for macroscopic examination.
Sighting study was conducted at the dose levels of 300 and 2000 mg/kg bw
(one female/dose) to determine the dose for main study.
the sighting study, no mortality or clinical signs were observed at 300
mg/kg bw. The animal showed a body weight gain over the observation
period that was considered to be within the historical range for this
strain. No abnormalities were noted at necropsy. In the main study, no
mortality was observed at 2000 mg/kg bw. Hunched posture was noted 4 h
after dosing in three animals. There were no other signs of systemic
toxicity noted in two animals. Animals showed body weight gains over the
observation period and that were considered to be within the historical
range for this strain. Epithelial sloughing of the non-glandular
epithelium of the stomach was noted at necropsy of one animal. No
abnormalities were noted at necropsy of four animals.
Oral LD50 (females) > 2000 mg/kg bw
the test conditions, the test material is not classified according to
the annex VI of the Regulation EC No. 1272/2008 (CLP).
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