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EC number: 264-140-6
CAS number: 63429-28-7
QSAR model, iSafeRat holistic approach v1.3, key study, validity 2:72h-ErC50 = 1.1 mg/L (95% CL: 0.91 - 1.3 mg/L).
assess the toxicity of the registered substance to aquatic algae, one
data point is available.
value (KREATiS, 2015), assessed as a key datapoint, is a QSAR. This QSAR
prediction (iSafeRat holistic approach v1.3) was performed on the
registered substance, to assess the inhibition of growth to algae of the
QSAR has been validated to be compliant with the OECD recommendations
for QSAR modelling (OECD, 2004) and predicts the endpoint value which
would be expected when testing the substance under experimental
conditions in a laboratory following OECD Guideline 201. The growth
inhibition of algae was determined using a validated QSAR for the Mode
of Action in question, (MOA 1, non-polar narcosis). Use of this MOA for
substituted α,β-unsaturated ketones has previously been demonstrated as
acceptable in a position paper (KREATiS, 2015; available in the Endpoint
Study Record). This QSAR is based on validated data for a training set
of 40 chemicals derived from 72-hour ErC50 tests on algae, for which the
concentrations of the test substance had been determined by chemical
analyses over the test period. The water solubility of the substance
given as input was experimentally measured at 13.4 mg/L. The
substance falls within the applicability domain of the model. The 72 -h
ErC50 based on growth rate was determined to be 1.1 mg/L (95%-Confidence
Limit: 0.91 - 1.3 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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