Registration Dossier
Registration Dossier
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EC number: 295-155-6 | CAS number: 91844-86-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Artemisia pallens, Compositae.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
iSafeRat® , KREATIS, 2021 :
72h-ErL50 = 57 mg/L (95% confidence interval: not determined)
72h-NOELr = 3.9 mg/L (95% confidence interval: not determined)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 57 mg/L
- EC10 or NOEC for freshwater algae:
- 3.9 mg/L
Additional information
To assess the toxicity of the registered substance to aquatic algae one QSAR prediction (KREATIS, 2021) is available.
The TOXICITY TO ALGAE (72-HOUR ErL50 and NOELr) was determined using iSafeRat® calculation method adapted for a mixture of compounds with the Mechanism of Action (MechoA) in question (MechoA 1.1, i.e. non-polar narcosis) (Bauer et al., 2018). This method has previously been validated in an internal publication for acute exposure of non-polar narcosis compounds (Bicherel and Thomas, 2014). The algorithm is based on two QSAR models which have been validated to be compliant with the OECD recommandations for QSAR modeling (OECD, 2004, 2007). The QSAR models are based on validated data from a training set of 40 chemicals (for 72-hour ErC50) and 31 chemicals (for NOECr) derived from 72-hour test on algae, for which the concentrations of the test item had been determined by chemical analyses over the test period. Further to this the effective loading rate of the WAF is determined by using a series of calculation steps using phase equilibrium thermodynamics and excluding the non-bioavailable fraction.
Each constituents of the test item which have been considered fall within the applicability domain of the model used to determine their individual TOXICITY TO ALGAE (72-HOUR ErL50 and NOELr). Not all the constituents were identified with the same MechoA (i.e. MechoA 1.1: non-polar narcosis). However the toxicity of the test item is determined by using a calculation method based on additivity approach for MechoA 1.1. To apply the calculation method to the test item, all the constituents were considered as non-polar narcotic prior to predict their individual aquatic toxicity. Therefore, the global result is considered as reliable with restrictions (mechanism domain).
Based on the composition provided by the sponsor, the TOXICITY TO ALGAE of the test item tested according to the WAF method was predicted as a loading rate of 5.7E+01 mg/L for the 72-HOUR ErL50 and 3.9E+00 mg/L for the NOECr.
95% confidence interval (α = 0.05): not determined
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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