5-fluoro-1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance on Safe Use

First-aid measures

General advice: show this safety data sheet to the doctor in attendance

If inhaled: if breathed in, move the person into fresh air. If symptoms persis, call a physician.

In case of skin contact: take off contaminated clothing and shoes immediatley. Wash off with soap and water. If symptoms persist, call a physician.

In case of eye contact: rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses. If eye irritation persists, consult a specialist.

If swallowed: if swallowed, rinse mouth with water (only if the person is conscious). Call a physician immediately.

Most important symptoms and effects, both acute and delayed

Risks: mutagenic effects

Indication of any immediate medical attention and special treatment needed

Treatment: treat symptomatically

Fire-fighting measures

Suitable extinguishing meda: water mist, dry powder, foam, carbon dioxide (CO2), sand, aqueous film forming foam (AFFF). Use extinguishing measures that are appropriate to loca circumstances and the surrounding environment.

Unsuitable extinguishing media: water spray jet.

Hazardous combustion products: boron oxides, nitrogen oxides (NOx), fluorine compounds, carbon oxides

Special protective equipment for firefighters: in the event of fire, wear self-contained breathing apparatus. Wear self-contained breathing apparatus for firefighting if necessary.

Further information: In the event of fire, cool tanks with water spray.

Accidental release measures

Personal precautions: avoid dust formation, avoid breathing dust, evacuate personnel to safe areas, keep away from open flames, hot surfaces and sources of ignition.

Environmental precautions: should not be released into the environment, do not flush into surface water or sanitary sewer system.

Methods for cleaning up:

Large spills: sweep up or vacuum with HEPA filter or via wet cleaning into suitable containers for disposal. Pick up and arrange without creating dust. Keep in properly labelled containers.

Small spills: Moisten a towel, cover the spill, pick up the spill or use HEPA vacuum.

Large spills + small spills: keep in suitable, closed containers for disposal. Treat recovered material as described in the section "Disposal considerations'

Handling and storage

Precautions for safe handling:

- Advice on safe handling: ensure all equipment is electrically grounded before beginnnig transfer operations. To avoid thermal decomposition, do not overheat. Use personal protective equipment as required. Keep away from heat and sources of ignition. Avoid inhalation, ingestion and contact with skin and eyes. Avoid formation of dust and aerosols.

- Advice on protection against fire and explosion: avoid dust formation.

- Hygiene measures: Handle in accordance with good industrial hygiene and safety practice.

Conditions for safe storage, including any incompatibilities

- Requirements for storage areas and containers: to maintain product quality, do not store in heat or direct sun-ligt. Store in original container. Keep containers tightly closed in a cool, well-ventilated place. Store at room temperature.

- Recommended storage temperature: 15 - 25 °C

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

Not regulated as a dangerous good

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

Not regulated as a dangerous good

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

Not regulated as a dangerous good

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

Not regulated as a dangerous good

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering measures:

Engineering controls should be used as the primary means to control possible exposures. Use process enclosures, local exhaus ventilation or other engineering controls to keep exposure levels below recommended exposure limits. All personal equipment should be based on a risk assessment. Consult a Environment Health Safety expert if necessary.

Personal protective equipment:

- Eye protection: safety glasses with side-shields

- Hand protection:

      Material: nitrile rubber

      Remarks: Take not of the information given by the producer concerning permeability and break through times, and of special workplace conditions (mechanical strain, duration of contact). Impervious gloves.

- Skin and body protection: closed work clothing, disposable one-piece overall.

- Respiratory protection: engineering controls should always be the primary method of controlling exposures. If respiratory protective equipment is needed for certain activities, the type as well as the corresponding protection factor will depend upon the risk assessment and air concentrations, hazarlds, physical and warning properties of substances present. Use only respiratory protection that conforms to international/national standards. Suitable mask wit hparticle filter P3

- Protective measures: the type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Stability and reactivity

Reactivity: non reasonably forseeable.

Chemical stability: stable under recommended storage conditions

Possibility of hazardous reactions: risk of dust explosion

Conditions to avoid: to avoid thermale decomposition, do not overheat. Heat, flames and sparks.

Materials to avoid: strong oxidizing agents.

Hazardous decomposition products: carbon oxides, boron oxides, fluorocarbons, nitrogen oxides (NOx), sulphur oxides

Disposal considerations

Waste treatment methods:

Product: must be incinerated in a suitable incineration plant holding a permit delivered by the competent authorities. In accordance with National, Federal, State and Local regulations.

Contaminated packaging: empty containers should be taken to an approved waste handling site for recycling or disposal.