Registration Dossier
Registration Dossier
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EC number: 812-520-2 | CAS number: 1259279-57-6
Oxidising properties
Administrative data
- Endpoint:
- oxidising solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 January - 15 February 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test O.1 (Test for oxidizing solids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.17 (Oxidising Properties (Solids))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-fluoro-1-(4-methylbenzenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
- EC Number:
- 812-520-2
- Cas Number:
- 1259279-57-6
- Molecular formula:
- C20H22BFN2O4S
- IUPAC Name:
- 5-fluoro-1-(4-methylbenzenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-63757044-AAA (T003686)
- Physical state: solid (powder)
- Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I16HD3479
- Analytical purity: 100%
- Expiration date: 3 September 2018
- Storage condition: at room temperature
Study design
- Contact with:
- powdered cellulose
- Duration of test (contact time):
- > 180 s
Results and discussion
Test results (Oxidising solids)open allclose all
- Key result
- Sample tested:
- 4:1 sample-to-cellulose ratio
- Parameter:
- mean burning time
- Result:
- > 180 s
- Remarks on result:
- other: flame, incandescence or glowing combustion
- Key result
- Sample tested:
- 1:1 sample-to-cellulose ratio
- Parameter:
- mean burning time
- Result:
- > 180 s
- Remarks on result:
- other: flame, incandescence or glowing combustion
- Sample tested:
- reference: 3:7 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 111 s
- Remarks on result:
- other:
- Remarks:
- flame, incandescence or glowing combustion
- Sample tested:
- reference: 2:3 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 50 s
- Remarks on result:
- other: flame, incandescence or glowing combustion
- Sample tested:
- reference: 3:2 mixture potassium bromate + cellulose
- Parameter:
- mean burning time
- Result:
- 17 s
- Remarks on result:
- other: flame, incandescence or glowing combustion
Any other information on results incl. tables
The mean burning time of both test item mixtures was more than the mean burning time of the 3:7 (w/w) reference mixture. According to this, the test item has no oxidizing properties.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The full test was performed to monitor the oxidizing properties of JNJ-63757044-AAA (T003686).
Based on the results obtained it was concluded that the test item has no oxidizing properties and is therefore not classified as a Division 5.1 substance.
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