Registration Dossier
Registration Dossier
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EC number: 215-311-9 | CAS number: 1321-12-6
Long-term toxicity to fish
Administrative data
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity, Biodegradability and Accumulation of a Number of Cl/N-Containing Compounds for Classification and Establishing Water Quality Criteria.
- Author:
- Canton JH et al.
- Year:
- 1 985
- Bibliographic source:
- Regulatory Toxicol Pharmacol 5: 123 - 131
- Reference Type:
- secondary source
- Title:
- 4-Nitrotoluene CAS 99-99-0
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Report for 17th SIAM
Materials and methods
- Principles of method if other than guideline:
- Test similar to the method described by Canton and Slooff (1982)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitrotoluene
- EC Number:
- 202-808-0
- EC Name:
- 4-nitrotoluene
- Cas Number:
- 99-99-0
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 4-nitrotoluene
- Analytical purity: > 99.5
Constituent 1
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
Test conditions
- Details on test conditions:
- - 50 animals (3 - 4 weeks old) each test
- Fish were fed with Tetramine, Tetraphyll
- Temperature: 23 ± 2 °C
- Photoperiod: (day-/night rhythm)
- 3-times a week adjustment of the concentration
EFFECT PARAMETERS MEASURED: mortality and behaviour
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: mortality + behaviour
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 2.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: mortality + behaviour
- Duration:
- 28 d
- Dose descriptor:
- LC50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
