Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: -
CAS number: -
Instillation of approximately 32 mg of the test substance (a volume of
approximately 0.1 mL) into one eye of each of three rabbits resulted in
effects on the iris and conjunctivae. Iridial irritation grade 1 was
observed in all animals and had resolved within 24 hours. The irritation
of the conjunctivae consisted of redness, chemosis and discharge and
completely resolved within 48 hours in one animal and within 72 hours in
the other two animals (Table 1).
Treatment of the eyes with 2% fluorescein 24 hours after test substance
instillation revealed no corneal epithelial damage.
Remnants of the test substance were present in the eye on Day 1 and on
the outside of the eyelids throughout the observation period. Red/purple
staining of the fur on the head and paws, caused by the test substance,
was noted throughout the observation period.
No symptoms of systemic toxicity were observed in the animals during the
test period and no mortality occurred.
Table 1. Individual eye irritation scores
Time after dosing
Fluor area (%)2
1Sentinel,2Green staining after fluorescein
treatment (percentage of total corneal area)
b: Remnants of the test substance in the eye, c: Remnants of the test
substance on the outside of the eyelids and e: Red/ purple staining of
the head and paws by the test substance.
Table 2. Mean value eye irritation scores.
Mean 24, 48 and 82 Hours
Table 3: Animal Specifications
Age at start (weeks)
Body weight (grams)
Prior to application
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again