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EC number: -
CAS number: -
Skin reactions/ irritation:
No irritation of the ears was observed in any of the animals
examined. No oedema was observed in any of the animals examined. Purple
staining by the test substance prevented scoring for erythema.
Body weights and body weight gain of experimental animals remained
in the same range as controls over the study period. The slight body
weight loss, noted in some animals, was considered not toxicologically
No mortality occurred and no symptoms of systemic toxicity were
observed in the animals of the main study.
Table 2 : Skin reactions, body weights and relative size auricular
Test substance1(% w/w)
Skin reactions dorsal surface ear
Acetone/olive oil (4:1).
size auricular lymph nodes( n: considered to be normal)
using a pipette with the tip cut off.
scoring due to purple staining of the ear.
Table 3. Disintegrations Per Minute (DPM) and Stimulation Index
DPM ± SEM
SI ± SEM
417 ± 64
0.8 ± 0.2
1.4 ± 0.4
361 ± 61
0.7 ± 0.2
509 ± 83
1.0 ± 0.2
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