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EC number: 925-384-5
CAS number: 90639-98-8
Not expected to affect fetal growth, viability, or morphological development.
No data avilable
Not expected to impair fertility, affect fetal growth, viability, or morphological development.
Data are available on Camphor base.
Study on rats
There was no maternal mortality during the
study. Absolute and relative liver weights exhibited a significant
dose-related increase, but did not exceed 10% of control values in any
individual group. Maternal toxicity consisted of alterations in food and
water consumption (absolute and relative) and decreased weight gain
during the treatment period. Food consumption was initially suppressed
by both 400 and 800 mg/kg/day CAM. but recovered to control levels by
the end of the treatment period. No effect on food consumption was seen
at 100 mg/kg/day CAM. Unlike the dose-dependent effects of CAM on food
intake, all three doses of CAM increased maternal water consumption
during one or more of the following measurement periods (gd 6 to 9; gd
12 to 15; gd 15 to 18). Although maternal body weights in all treatment
groups were within 5% of control values at all gestational ages,
maternal weight gain during the treatment period in the 800 mg/kg/day
group was significantly reduced. Examination of the uterine contents
revealed that CAM, even at 800 mg/kg/day, had no adverse effect on fetal
growth, viability, or morphological development. In summary, CAM does
not affect fetal growth, viability, or morphological development at
doses causing minor maternal toxicity. ( NTP
Study on rabbits
was no maternal mortality in any of the experimental groups. Maternal
body weights in the CAM-treated groups were comparable to controls at
all gestational ages. However, maternal weight gain tended to decrease
with increasing dose of CAM. Maternal food consumption in all three CAM
groups was similar to controls throughout gestation. Examination of the
uterine contents revealed that CAM had no effect on fetal growth,
viability, or morphological development.
results from this study indicate that CAM is neither developmentally
toxic nor toxic to the doe at doses as high as 400 mg/kg/day (NTP
Camphor crosses the placenta and has been
implicated in fetal and neonatal death. It has been used to induce
abortions. Camphor poisoning during pregnancy was reported in four cases
and, in each case, camphorated oil was mistaken for castor oil. The
topical use of camphorated oil in pregnancy was not associated with
teratogenic effects (IPCS, 1989).
are no experimental and/or literature specific data on L-CARNITINEAMIDE
analysis was carried out by calculation tools, but results were not
exhaustive, since it is a salt, public programs are outside the
application field and can not be used. Therefore it has been
the base (Camphor;
CAS: 76 -22 -2; EC: 200
-945 -0) and
CAS: 541 -15 -1; EC: 208 -768 -0) of
the substance, because
pathway of the substance is dissociate to its base and counter-ion,
Camphor and Levocarnitine, and Camphor undergos to further
transformation to Camphoric acid by ossidative metabolism.
No data of effects on fertility are
Based on read across approach with its
Camphor base, L-Carnitineamide D-Camphorated salt is not expected to
affect fetal growth, viability, or morphological development. Despite
were reported four case in which Camphor crosses the placenta and has
been implicated in fetal and neonatal death, when camphorated oil was
mistaken for castor oil [*-4], controlled studies on rats 
and rabbits  confirmed that Camphor not affect fetal
growth, viability, or morphological development.
Any details about data available are
reported in the report attached at the point 13: Assessment Report.
source: Hazardous Substances Data Bank – HSDB - U.S. National Library of
Medicine, 8600 Rockville Pike, Bethesda, MD 20894, National Institutes
of Health, Department of Health & Human Services
Poisons Information Monograph 095: Camphor. (May 1989). Available from,
as of February 5,
Developmental Toxicity of
d-Camphor (CAS No. 464-49-3) in Sprague Dawley (CD®) Rats, NTP Study:
Developmental Toxicity of
d-Camphor (CAS No. 464-49-3) in New Zealand White (NZW) Rabbits, NTP
Based on read across approach, theL-Carnitineanide
D-Camphorated is not expected to be carcinogen.
According to the Regulation
D-Camphoratedis is classified as Non toxic to reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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