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EC number: 925-384-5
CAS number: 90639-98-8
LD50 Mouse oral: 1310 mg/kg
are no experimental and/or literature specific data on L-CARNITINEAMIDE
analysis was carried out by calculation tools, but results were not
exhaustive, since it is a salt, public programs are outside the
application field and can not be used. Therefore it has been
the base (Camphor;
CAS: 76 -22 -2; EC: 200
-945 -0) and
CAS: 541 -15 -1; EC: 208 -768 -0) of
the substance properties,
because the metabolism
pathway of the substance is dissociate to its base and counter-ion,
Camphor and Levocarnitine, and Camphor undergos to further
transformation to Camphoric acid by ossidative metabolism.
The Camphor oral acute toxicity was
investigated in dogs, rabbits and mice and were noted effects on central
nervous system: in dogs the
lethal dose was foud at 9 -14 g and the general effects were preliminary
stimulation with subsequent paralysis of the central nervous system and
the death was due to asphyxia [*-9]. In rabbits systemic
camphor poisoning effects were noted on the pupils, as mydriasis; in
this case no concentration was reported [*-10].
the identification of Camphor base concentration toxicity an LD50 on Mouse,
oral was foud at 1310 mg/kg [*-11] .
On the same specie the conunter-ion
reported in literature data is higher: about 19.2
Any details about data available are
reported in the report attached at the point 13: Assessment Report.
Secondary source: Hazardous
Substances Data Bank – HSDB - U.S. National Library of Medicine, 8600
Rockville Pike, Bethesda, MD 20894, National Institutes of Health,
Department of Health & Human Services
Clarke, M. L., D. G. Harvey and D. J. Humphreys. Veterinary Toxicology.
2nd ed. London: Bailliere Tindall, 1981., p.125 **PEER REVIEWED**
Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois:
Charles C. Thomas, 1974., p. 226 **PEER REVIEWED**
Lewis, R.J. Sax's Dangerous
Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY:
Van Nostrand Reinhold, 1996., p. 641 **PEER REVIEWED**
Thomson Healthcare. PDR for
Nutritional Supplements. Thomson Health Care Inc. Montvale, NJ. p.258
(2001) **PEER REVIEWED**
In consideration of the fact that
all literatura data are found from secondary source, that the original
reports are not available and that their reliability is comparable,
the lowest LD50 on mouse of 1310 mg/kg (Lewis, 1996) was
considered as inclonclusive to led to an official classification
According to the Regulation
EC1272/2008 (CLP) L-Carnitineamide
D-Camphorated is not classified for Acute oral Toxicity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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