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EC number: 420-380-5
CAS number: 136465-81-1
A tendency to increasing values of water solubility was noticed from the
results of days 1, 2 and 3. Therefore vessel 3 was equilibrated for a
further fourth day. The water solubility value for the fourth day was
not significant different to the value obtained on day 2. An average was
therefore generated for the last three experimental days. The results
are reported in the table below;
pH at 30 ⁰C (hours)
Initial PTH-Decahydroamide Weight (g)
Solubility (in g/L saturated solution)
Found PTH-Decahydroamide (g) in 200 mL water
Average (last 3 days)
Rel. Std. Dev.
The water solubility of PTH-decahydroamide (Ro 31-9373/000) was
determined to be 1.65 g/L at 20 ⁰C using the flask method. The standard
deviation between the solubilities for the last three days was 6% which
is below the maximum 15% accepted in the guidelines.
The water solubility of PTH-decahydroamide was determined using the EU
method, A.6 (1992). The water solubility of PTH-decahydroamide (Ro
31-9373/000) was determined to be 1.65 g/L at 20 ⁰C using the flask
method. PTH-decahydroamide was concluded to be soluble in water.
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