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Diss Factsheets

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Modern GLP study peformed on the basis of EC directive 92/69/EEC A.2.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Principles of method if other than guideline:
Not applicable.
GLP compliance:
yes
Type of method:
method according to Siwoloboff

Test material

Constituent 1
Reference substance name:
PTH-Decahydroamide
IUPAC Name:
PTH-Decahydroamide
Constituent 2
Reference substance name:
Ro 31-9373/000
IUPAC Name:
Ro 31-9373/000
Details on test material:
The test material received from F. Hoffmann-La Roche Ltd was a white solid powder from lot no. 25927 with a purity of 99.8%.

Results and discussion

Boiling point
Boiling pt.:
364.8 °C

Any other information on results incl. tables

TABLE 1 - BOILING TEMPERATURE OF PTH-DECAHYDROAMIDE

Boiling Temperature at atmospheric pressure (⁰C)

Atmospheric pressure (kPa)

Boiling Temperature corrected for normal atmospheric pressure (⁰C)

363.5

101.60

363.35

364.5

96.59

366.45

362.8

96.59

364.65

 

Average

364.8

 

Std dev.

1.56 (n=3)

 

Relative std dev.

0.4%

The mean boiling point was determined to be 364.8 ⁰C. At a temperature near 300 ⁰C the test substance turned to a yellow-brown colour.

Applicant's summary and conclusion

Conclusions:
The mean boiling point was determined to be 364.8 ⁰C. At a temperature near 300 ⁰C the test substance turned to a yellow-brown colour.
Executive summary:

The boiling point of PTH-decahydroamide was obtained using the EU method A.2. The mean boiling point was determined to be 364.8 ⁰C. At a temperature near 300 ⁰C the test substance turned to a yellow-brown colour.