Registration Dossier
Registration Dossier
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EC number: 420-960-8 | CAS number: 77214-82-5 JOF 2822 5F; JOF 2822 5FL; JOF 4443
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.4
- GLP compliance:
- yes
Test material
- Reference substance name:
- Iron (III) tris(4-methylbenzenesulfonate)
- EC Number:
- 420-960-8
- EC Name:
- Iron (III) tris(4-methylbenzenesulfonate)
- Cas Number:
- 77214-82-5
- Molecular formula:
- C21H21FeO9S3
- IUPAC Name:
- iron(3+) tris(4-methylbenzene-1-sulfonate)
Constituent 1
Test animals
- Species:
- other: rabbit (w), Stamm HC: NZW
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: moistened with water
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- ( mean score 2)
- Time point:
- other: overall at 24,48 and 72 h
- Score:
- 1.7
- Max. score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24,48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24,48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- ( mean score 2)
- Time point:
- other: overall at 24,48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24,48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: max. duration: d; Max. value at end of observation period: 0 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 14 days
- Other effects:
- On day 7 the skin of two of 3 animals was coverd with white to yelow, scaly layer.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
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