Registration Dossier
Registration Dossier
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EC number: 420-960-8 | CAS number: 77214-82-5 JOF 2822 5F; JOF 2822 5FL; JOF 4443
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was carried out in accordance with internationally valid GLP principles.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Iron (III) tris(4-methylbenzenesulfonate)
- EC Number:
- 420-960-8
- EC Name:
- Iron (III) tris(4-methylbenzenesulfonate)
- Cas Number:
- 77214-82-5
- Molecular formula:
- C21H21FeO9S3
- IUPAC Name:
- iron(3+) tris(4-methylbenzene-1-sulfonate)
Constituent 1
Test animals
- Species:
- other: rat, Wistra Stamm Bor: WISW (SPF Cpb)
Administration / exposure
- Vehicle:
- other: deionised water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 350 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 1500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 2 - Clinical signs:
- other: Signs of toxicity related to dose levels: All signs of intoxication piloerection was observed in all dose groups, from 2000 mg/kg bw additionally sedation and increased salivation. Symptoms ocured 30 min after application and stayed up to day 11.
- Gross pathology:
- Effects on organs:
Deadths in 2000 and 2500 mg/kg:
The stomach was filled with yellow-brownish, partially solid mass, the stomach and intestine mucousa was redened. In each one female and one male of 2000 mg/kg the abdomen was filled with dark yellow liquid. In the female died at 1500 mg/kg the stomach was filled with an aquatic liquid , the mucousa reded and the intestine content black discoloured.
All animals which were killed at the end of the studydid not show any effects.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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