A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 26, 1992 - October 29, 1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This study has been performed according to OECD 104 (1981), EU Method A.4 (1984) and according to GLP principles. But as the vapour pressure of the substance is below 1 Pa, the used method is considered to be not the most suitable method. Additionally, regression line was constructed using ln p data instead of log p. Limited information available to verify the composition of the used test substance.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

(1981)

Deviations:

yes

Remarks:

as the vapour pressure of the substance is below 1 Pa, there are more suitable methods than the static method

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

(1984)

Deviations:

yes

Remarks:

as the vapour pressure of the substance is below 1 Pa, there are more suitable methods than the static method

GLP compliance:

yes

Type of method:

static method

Test material

Test material information

Constituent 1

Reference substance name:

A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

EC Number:

411-070-0

EC Name:

A mixture of: 2,4 -bis(N'-(4-methylphenyl)ureido)toluene; 2,6 -bis(N'-(4-methylphenyl)ureido)toluene

Molecular formula:

C23H24N4O2

IUPAC Name:

3-(2-methyl-5-{[(4-methylphenyl)carbamoyl]amino}phenyl)-1-(4-methylphenyl)urea

Details on test material:

- Name of test material (as cited in study report): KY-ET
- Appearance: Light yellow solid
- Storage condition of test material: At room temperature in the dark

Results and discussion

Vapour pressure

Temp.:

25 °C

Vapour pressure:

0.195 Pa

Any other information on results incl. tables

- The vapour pressure measurements were started at 36.43°C. The vapour pressure decreased with subsequent measurements, but this decrease was negligible after measurement 100. During measurement 114 the temperature of the thermostatic bath in which the sample vessel is immersed was lowered to 30.12°C and finally during measurement 131 to 23.81°C. During measurement 154 the experimental part of the study was finished.

- Results based on which the curve was plotted:

Serie	Measurements	Temperature [°C]	Mean vapour pressure, p [Pa]	Ln (p)
1	100 -113	36.43	0.476	-0.74
2	120 -130	30.12	0.272	-1.30
3	135 -153	23.81	0.183	-1.70

- Fitting this data according to Clark & Glew gives a value of 0.195 Pa (CV: 12%) for the vapour pressure of the test substance at 25 degrees Celsius

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance was determined to be 0.195 Pa (at 25 degrees Celsius), using with the static method according to OECD 104 (1981), EU Method A.4 (1984) and according to GLP principles.