Reaction Mass of Cyclohexanepropanol, 2,2,6-trimethyl-a-propyl-, (alpha.R,1R,6S)- and Cyclohexanepropanol, 2,2,6-trimethyl-a-propyl-, (alpha.S,1R,6S)-

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From July 30 to August 07, 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately characterised with its isomers composition. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on November 29 and 30, 2010 / signed on April 11, 2011

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

327 °C

Atm. press.:

1 013 hPa

Decomposition:

no

Table 4.3/1: Observations

 

Determination	Boiling Point	Atmospheric Pressure
Second determination	294.4 °C (567.6 K)	99904 Pa
Third determination	326.7 °C (599.9 K)	99683 Pa
Fourth determination	325.2 °C (598.4 K)	99673 Pa

 

The duplicate determination (experiments 2 and 3) showed unusual variation. Therefore, it was decided to perform a fourth experiment. As the fourth determination confirmed the result of the third determination, experiments 3 and 4 were used for evaluation. After cooling down, the test item was unchanged.

 

Table 4.3/2: Corrected values following Sidney-Young

 

Determination	Boiling Point	Pressure in Pa	Corrected Boiling Point
Third determination	326.7 °C (599.9 K)	99683 Pa	327.6 °C (600.7 K)
Fourth determination	325.2 °C (598.4 K)	99673 Pa	326.1 °C (599.2 K)
Mean			326.9 °C (600.0 K)

 

Mean ± standard deviation (after correction following Sydney Young) = 326.9 ± 1.1 °C (600.0 ± 1.1 K).

 

Executive summary:

The boiling point of the test substance was determined under GLP according to OECD 103/EU A2 guideline, by Siwoloboff (capillary) method.

The determination was performed in triplicate and the mean final temperature was retained (2 consistent results), and corrected to normal atmospheric pressure. No change in appearance was observed.

 

The normal boiling point (corrected to standard atmP) of the test substance was determined as 327°C.

Description of key information

Measured (initial) boiling point = 326°C under 99.7 kPa; Corrected value = 327°C to normal atmP

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

327 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore it is considered as a key study, and the result is retained as key data.