Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-829-9 | CAS number: 3624-77-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h): 10 mg/L based on the respiration of activated sludge microorganisms (OECD 209) (read-across)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 300 mg/L
- EC10 or NOEC for microorganisms:
- 10 mg/L
Additional information
No studies investigating the toxicity of Reaction products of oleoyl sarcosine with sodium hydroxide to microorganisms are available. Therefore, data from the corresponding acid, (Z)-N-methyl-N-(1-oxo-9-octadecenyl) glycine (CAS 110-25-8), are used as read-across.
This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the category justification in IUCLID Section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have similar chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as dissociation of the acidic form of the substance, this read across can be considered as justified.
For the toxicity of the read-across substance (Z)-N-methyl-N-(1-oxo-9-octadecenyl) glycine (CAS 110-25-8) to microorganisms two studies according to OECD 209 are available. The key study was carried out under GLP-conditions with domestic activated sludge as inoculum (Muckle, 2009). Effects on the respiration rate of the microorganisms were observed at concentrations far beyond the water solubility and the measured data showed a large variety, with 95% confidence levels for the EC50 (3 h) between 480 mg/L and 7200 mg/L. The EC50 (3 h) was extrapolated to be 1300 mg/L. For PNEC derivation the NOEC (3 h) of 10 mg/L was used. The supporting study did not follow GLP standards (Bader, 1989). In this study, the IC50 (3 h) for respiration inhibition was above the highest test concentration of 100 mg/L.
Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5.) which is characterized by a comparable structure, it can be concluded that Reaction products of oleoyl sarcosine with sodium hydroxide will show similar results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
