Registration Dossier
Registration Dossier
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EC number: 611-068-1 | CAS number: 5393-81-7
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Remarks:
- Trend analysis; QSAR Toolbox 4.5
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- 1. SOFTWARE
QSAR-Toolbox
2. MODEL (incl. version number)
4.4
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS: 5393-81-7
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: Environmental Hazards -> Short-term Aquatic Toxicity invertebrates (EC50)
- Unambiguous algorithm: Linear approximation from structurally similar substances
- Defined domain of applicability: Please refer to the attached assessment under 'attached justification'
- Appropriate measures of goodness-of-fit and robustness and predictivity: Please refer to the attached assessment under 'attached justification'
5. APPLICABILITY DOMAIN
Please refer to the attached assessment under 'attached justification'
6. ADEQUACY OF THE RESULT
Please refer to the attached assessment under 'attached justification'
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Trend analysis; QSAR Toolbox 4.5
- GLP compliance:
- no
- Remarks:
- Trend analysis
Test material
- Reference substance name:
- 2-hydroxydecanoic acid
- EC Number:
- 611-068-1
- Cas Number:
- 5393-81-7
- Molecular formula:
- C10-H20-O3
- IUPAC Name:
- 2-hydroxydecanoic acid
- Test material form:
- solid
- Details on test material:
- Purity: 98.5%
1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 140 mg/L
Applicant's summary and conclusion
- Conclusions:
- Based on the present trend analysis performed with the OECD QSAR Toolbox 4.4 the EC50 for short-term aquatic toxicity to invertebrates was predicted to be 140 mg/L.
- Executive summary:
The EC50 for short-term aquatic toxicity to invertebrates of 2-Hydroxydecanoic Acid was estimated by a linear approximation based on structurally similar substances. A trend analysis was performed with the QSAR Toolbox 4.5. The EC50 for short-term aquatic toxicity to invertebrates was predicted to be 140 mg/L. The substance does not need to be classified according to Regulation (EU) No. 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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