O-isopropyl ethylthiocarbamate

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate.

Data source

Reference

Reference Type:

publication

Title:

Interspecies Comparisons of Skin Irritancy

Author:

Nixon G, Tyson C & Wertz W

Year:

1975

Bibliographic source:

Toxicology and Applied Pharmacology 31, 481-490 (1975)

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

This test followed the revised Federal Hazardous Substances Act (FHSA) procedure that had been proposed by the FDA (Edwards, 1972), with a 4-hour rather than 24-hour exposure.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

O-isopropyl ethylthiocarbamate

EC Number:

205-517-7

EC Name:

O-isopropyl ethylthiocarbamate

Cas Number:

141-98-0

Molecular formula:

C6H13NOS

IUPAC Name:

N-ethyl(propan-2-yloxy)carbothioamide

Test material form:

liquid

Details on test material:

IPETC is prepared through reacting ethoxycarbonyl isothiocyanate/ Ethyl isothiocyanatoformate (CAS 16182-04-0) with propan-2-ol/ isopropyl alcohol (CAS Number 67-63-0) and Butan-1-ol/ butyl alcohol (CAS Number 71-36-3).

IPETC/O-isopropyl ethylthiocarbamate contains propan-2-ol (CAS number 67-63-0) and Butan-1-ol (CAS number 67-63-0) which are an integral part of the substance.
Propan-2-ol (CAS number 67-63-0) and Butan-1-ol (CAS number 67-63-0) are both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate. Therefore, Propan-2-ol (CAS number 67-63-0) and Butan-1-ol (CAS number 67-63-0) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.

EC Name: propan-2-ol
CAS Number :67-63-0
EC Number:200-661-7
CAS Name: isopropyl alcohol

EC Name: Butan-1-ol
CAS Number : 71-36-3
EC Number: 200-751-6
CAS Name: butyl alcohol

Method

Type of population:

not specified

Subjects:

No details provided

Ethical approval:

not specified

Route of exposure:

dermal

Reason of exposure:

intentional

Exposure assessment:

not specified

Details on exposure:

Each subject afforded 8 test sites about 4 cm square, aligned 4 on each side of the back about 5 cm from the midline. Sites were vertically spaced 3 cm apart in the area between the scapula and the waist. When testing was done on both intact and abraded sites, 4 materials were tested on each subject. To reduce discomfort from irritating substances, abrasions were made in a single criss-cross design, rather than in the tic-tac-toe pattern specified for the rabbit test. Materials were tested on both abraded and intact sites of human volunteers whenever appropriate. Materials that were known or suspected to be corrosive or severely irritating were either not applied to humans or were not tested on abraded sites.

Examinations:

- Other: skin irritation/corrosion

Medical treatment:

Most subjects were reexamined after one month to see whether any delayed reactions had occurred. Humans who had shown evidence of severe reactions were followed for as long as necessary to determine whether permanent damage had occurred.

Results and discussion

Clinical signs:

Not reported.

Results of examinations:

The mean scores for irritant response of intact and abraded human skin were 0.0 (negligible) and 0.8 (slight), respectively. The Primary Irritation Index (PII) was 0.4, and the tissue destruction fraction was 0/6, whether the skin was intact or abraded.

Effectivity of medical treatment:

Not applicable

Outcome of incidence:

Not applicable

Any other information on results incl. tables

The mean scores for irritant response of intact and abraded human skin were 0.0 (negligible) and 0.8 (slight), respectively. The Primary Irritation Index (PII) was 0.4, and the tissue destruction fraction was 0/6, whether the skin was intact or abraded.

Applicant's summary and conclusion

Conclusions:

The mean scores for irritant response of intact and abraded human skin were 0.0 (negligible) and 0.8 (slight), respectively. The Primary Irritation Index (PII) was 0.4, and the tissue destruction fraction was 0/6, whether the skin was intact or abraded.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/f O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .