Registration Dossier
Registration Dossier
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EC number: 500-013-6 | CAS number: 9004-78-8 1 - 2.5 moles ethoxylated
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment based on the properties of the indvidiual constituents of the substance
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenol, ethoxylated
- EC Number:
- 500-013-6
- EC Name:
- Phenol, ethoxylated
- Cas Number:
- 9004-78-8
- Molecular formula:
- not applicable - the substance is a multiconstituent substance
- IUPAC Name:
- 2-phenoxyethan-1-ol
- Test material form:
- liquid
Constituent 1
Results and discussion
In vitro
Results
- Remarks on result:
- other: An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that the substance shall be classified as Eye Dam. 1; H318.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that the substance shall be classified as Eye Dam. 1; H318.
- Executive summary:
The capacity of Phenol, ethoxylated to be irritant to the eye was assessed based on the available information on its constituents.
2-phenoxyethanol is classified as Eye Irrit 2; H319 and 2-(2-phenoxyethoxy)ethanol as Eye Dam. 1; H318 based on available experimental data.
Considering the structural similarities between the constituents of Phenol, ethoxylated and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol can be expected to be damaging to the eye.
It is concluded that Phenol, ethoxylated does not meet the criteria for classification as irritant to the eye according to the CLP Regulation. However, it is proposed to conduct testing on the substance in order to confirm the conclusion.
In accordance with the CLP Regulation, since the concentration of constituents of Phenol, ethoxylated classified as damaging to the eye is above 3%, the substance shall be classified as Eye Dam. 1; H318.
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