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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The Acute Oral Toxicity of Phenol, ethoxylated (CAS 9004-78-8 / EC 500-013-6) was assessed based on the available information on its constituents.

2-phenoxyethanol has a Harmonised Classification as Acute Tox 4; H302, which was confirmed during the REACH Registration of the substance.

2-(2-phenoxyethoxy)ethanol was concluded not to meet the criteria for classification for this endpoint based on available experimental data on the substance.

Considering the structural similarities between the constituents of Phenol, ethoxylated and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol is not expected to be toxic following an acute exposure via the oral route.

While it can be concluded according to the CLP Regulation that Phenol, ethoxylated does not meet the criteria for classification as toxic following an acute oral exposure, it is suggested to classify the substance as Acute Tox 4; H302 to compensate the lack of information on one of the constituents of the substance.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
other: expert assessment
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessment based on the properties of the indvidiual constituents of the substance
Qualifier:
no guideline required
Principles of method if other than guideline:
An assessment was conducted based on the properties of the indvidiual constituents of the substance.
GLP compliance:
no
Test type:
other: Assessment based on the properties of the indvidiual constituents of the substance
Limit test:
no
Remarks on result:
other: An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated should be classified as Acute Tox 4; H302.
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated should be classified as Acute Tox 4; H302.
Executive summary:

The Acute Oral Toxicity of Phenol, ethoxylated was assessed based on the available information on its constituents.

2-phenoxyethanol is associated to a Harmonised Classification as Acute Tox 4; H302, which was confirmed during the REACH Registration of the substance.

2-(2-phenoxyethoxy)ethanol was concluded not to meet the criteria for classification for this endpoint based on available experimental data on the substance.

Considering the structural similarities between the constituents of Phenol, ethoxylated, and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol is not expected to be toxic following an acute exposure via the oral route.

While it can be concluded according to the CLP Regulation that Phenol, ethoxylated does not meet the criteria for classification as toxic following an acute oral exposure, it is suggested to classify the substance as Acute Tox 4; H302 to compensate the lack of information on one of the constituents of the substance.

Additional information

Justification for classification or non-classification

An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated should be classified as Acute Tox 4; H302.