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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 Jan - 19 Mar 2018
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
water solubility below detection limit of HPLC
according to guideline
OECD Guideline 105 (Water Solubility)
Version / remarks:
Type of method:
flask method
Water solubility:
< 0.518 mg/L
Conc. based on:
test mat. (dissolved fraction)
20 °C

Calculation of water solubility
The water solubility of test item was regarded as < 0.518 mg/L because the test item concentration in the HPLC analytical sample was less than the limit of quantification.

Treatment of numerical values
Values were rounded off in accordance with Japanese Industrial Standards (JIS) Z 8401:1999 rule B. The water solubility was rounded off to 3 significant figures. The pH of test solutions was rounded off to one decimal place.

Results and discussion
Measurement results

Sample name


Measured value [mg/L]




< 0.518

< 0.518


< 0.518


Water solubility of test item (20 °C): < 0.518 mg/L

The water solubility was less than the concentration calculated from the limit of quantification. However, the analytical method was judged to be valid because the average of recovery rates was larger than 90%. Therefore, it was concluded that test results were acceptable. 

Description of key information

< 0.518 mg/L at 20 °C (flask method, OECD 105)

Key value for chemical safety assessment

Additional information

The water solubility was below the limit of quantification of the HPLC. However it was concluded that the test results were acceptable.