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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 December 2017 to 01 June 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
3.7 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: ± 0.4 mg/L
Details on results:
The water solubility of the test item was determined to be 3.7 ± 0.4 mg/L at 20°C

Table 1- Summary of water solubility results

Days at 30°C

Sample

Concentration
(mg/L)

pH

1

1A

4.117

9.5

1B

3.514

9.6

2

2A

4.132

9.6

2B

4.067

9.5

3

3A

3.366

9.5

3B

3.114

9.4

Mean = 3.72 mg/L

SD = 0.44 mg/L

RSD = 11.9 %

Conclusions:
The water solubility of the test item was determined to be 3.7 ± 0.4 mg/L at 20 °C.
Executive summary:

The water solubility of the test item was determined in a study following OECD 105 and EC Method A6 guidelines, using the flask method. The water solubility of the test item was determined to be 3.7 ± 0.4 mg/L at 20°C.

The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.

Description of key information

The water solubility of the test item was determined to be 3.7 ± 0.4 mg/L  at 20 °C.

Key value for chemical safety assessment

Water solubility:
3.7 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined in a study following OECD 105 and EC Method A.6 guidelines, using the flask method (Dunning 2018). The water solubility of the test item was determined to be 3.7 ± 0.4 mg/L at 20 °C.

The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.