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EC number: 261-999-9 | CAS number: 59963-30-3
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 December 2017 to 01 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test item was determined to be 0.0003 Pa at 25°C.
- Executive summary:
The vapour pressure of the test item was determined in a study following OECD 104 and EC Method A4 guidelines, by the effusion method using isothermal thermogravimetry analysis. The vapour pressure of the test item was determined to be 3 x 10-4 Pa at 25°C.
The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.
Reference
For runs 1 to 3, there were initial high weight losses at lower temperatures. This was indicative of degassing of the sample, so the data from run 4 was used. A fresh sample was then used for runs 5 and 6. There was initial degassing in the first of these runs, so the data from run 6 was also used. The data from runs 4 and 6 were therefore used for calculations.
Table 1- Summary of results from runs 4 and 6
Parameter |
Run 4 |
Run 6 |
Correlation (R2) |
0.9428 |
0.9656 |
Slope |
-4042 |
-3345 |
Intercept |
9.551 |
7.933 |
log10PTat 25°C |
-4.0 |
-3.3 |
PT(Pa) at 25°C |
9.9 x 10-5 |
5.2 x 10-4 |
Table 2- Vapour pressure measurements (Run 4)
Temperature |
Evaporation rate,VT |
log10VT |
log10PT |
138.57 |
0.0000002689 |
-4.085 |
-0.3611 |
148.53 |
0.0000006267 |
-3.718 |
0.03205 |
158.48 |
0.000001069 |
-3.486 |
0.2802 |
168.44 |
0.000001428 |
-3.360 |
0.4148 |
178.41 |
0.000001801 |
-3.259 |
0.5226 |
Table 3- Vapour pressure measurements (Run 6)
Temperature |
Evaporation rate,VT |
log10VT |
log10PT |
138.37 |
0.0000003367 |
-3.988 |
-0.2567 |
148.33 |
0.0000006363 |
-3.711 |
0.03912 |
158.29 |
0.0000009727 |
-3.527 |
0.2363 |
168.27 |
0.000001291 |
-3.404 |
0.3679 |
178.24 |
0.000001614 |
-3.307 |
0.4717 |
Description of key information
The vapour pressure of the test item was determined to be 0.0003 Pa at 25°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure of the test item was determined in a study following OECD 104 and EC Method A4 guidelines, by the effusion method using isothermal thermogravimetry analysis (Dunning 2018). The vapour pressure of the test item was determined to be 3 x 10-4 Pa at 25°C.
The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.
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