Registration Dossier
Registration Dossier
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EC number: 948-047-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
A reliable study was available for the readacross substance Decanoic acid, mixed diesters with octanoic acid and propylene glycol assessing the short-term toxicity to fish. No mortality was observed at the limit test concentration of 39 mg/L. Therefore, the 96-hour LC50 for the test substance was ≥39 mg/L. The test substance was above the limit of solubility as droplets were observed on the water surface.
Two studies are presented here for short term toxicity to invertebrates, both using read-across substances. Both studies are reliable (Klimisch 2). The key study was carried out on the read across substance Butylene Glycol Dicaprylate/Dicaprate and resulted in a 48 hour EC50 for Daphnia magna of >2.0 mg/L based on immobilisation. The other study was carried out on the read across substance Decanoic acid, mixed diesters with octanoic acid and propylene glycol and resulted in a 48 hour EC50 for Daphnia magna of >2.7mg/L.
The toxicity of the read across substance, fatty acids, C16-18, esters with ethylene glycol, was assessed for the algal species Desmodesmus subspicatus (previous name: Scenedesmus subspicatus). Over the 72-hour time frame there was a positive effect on the growth of the cells compared to the control. Based on this the 72-hour EC50 of the substance is considered >100mg/L.
The toxicity of the read across substance Butylene Glycol Dicaprylate/Dicaprate to microorganisms was assessed, according to EC Guideline 88/302/EC (1988). No activated sludge respiration inhibition observed at any test concentration. Therefore, the 3 -hour EC50 for the test substance was >1099 mg/L and the NOEC was 1099 mg/L.
The lowest EC50 from the available fish, aquatic invertebrate and algae studies was determined for the invertebrate Daphnia magna. The key studied was carried out on the read across substance, C 3 -C 10 fatty acid-1, 3-butanedioester and resulted in a 48 hour EC50 for Daphnia magna of >2.0 mg/L based on immobilisation.
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