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EC number: 208-235-2
CAS number: 517-23-7
A-Lactone was evaluated for mutagenic activity in the Ames test. A
standard plate incorporation and a preincubation modification assay in
absence and in presence of an exogenous metabolic activation system (S9)
were performed. Five Salmonella typhimurium tester strains (TA1535,
TA97, TA98, TA100, and TA102) were employed. The activity of the S9 -mix
and the responsiveness of the tester strains were verified by including
appropriate controls into each experiment. The substance was dissolved
in water. Concentration ranges between 0.1 to 5 mg/plate were chosen for
the main experiments.
No significant increase in the number of revertant colonies was apparent
in all five tester strains (TA1535, TA97, TA98, TA100, and TA102) using
both methods, after treatment with A-Lactone.
Based on these data A-Lactone can be considered as not mutagenic in the
Ames test under the described experimental conditions.
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