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EC number: 208-235-2
CAS number: 517-23-7
Reduction of growth rate (ErCx,
NOEC [r]) is the preferred endpoint according to OECD 201 and for
regulatory purposes in the EU. Results relating to yield (EyCx, NOEC
[y]) were calculated to fulfil regulatory requirements in some countries
(but not in the EU) and are given in the results section of this report.
The toxicity of α-acetyl-ɣ-butyrolacton to algae (Desmodesmus
subspicatus) was determined according to EU method C.3 ‘Freshwater Alga
and Cyanobacteria, Growth inhibition test’ (2009) which is equivalent to
OECD Guideline for Testing of Chemicals No. 201 (2006). Exponentially
growing algal cells were exposed for a period of 72 hours to range of
concentrations, nominally 0.88, 1.9, 4.3, 9.4, 21, 45 and 100 mg/L of
α-acetly-ɣ-butyrolacton dissolved in dilution water. The cell densities
were measured at 24 hours intervals. Inhibition of the algal population
was measured as reduction in growth rate [r], relative to control
cultures grown und identical conditions. The results are expressed in
terms of geometric mean measured concentrations. Effective
concentrations ranged from 96.9 % to 113.2 % of nominal values at 0
hours, from 42.0 to 76.4 % of nominal values at 24 hours, from 28.8 % to
71.7 % of nominal values at 48 hours and from 17.9 % to 73.7 % of
nominal values at 72 hours. An ErC10 of 11.31 mg/L and an ErC50 of >100
mg/L were measured; a NOEC[r] of 4.246 mg/L and a LOEC[r] of 8.276 mg/L
were calculated. This toxicity study is classified as acceptable and
satisfies the guideline requirements for the acute algae study.
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