Magnesium dipropan-2-olate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1948

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

publication

Title:

FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY

Author:

Smyth HF & Carpenter CP

Year:

1948

Bibliographic source:

J Ind Hyg Toxicol 30(1):63-68

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

detailed description of methodology and results is lacking

GLP compliance:

no

Remarks:

Study pre-dates GLP requirements

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propan-2-ol

EC Number:

200-661-7

EC Name:

Propan-2-ol

Cas Number:

67-63-0

Molecular formula:

C3H8O

IUPAC Name:

propan-2-ol

Details on test material:

- Name of test material (as cited in study report): Propanol-(2) (2-propanol, isopropyl alcohol )
- Substance type: organic
- Physical state: liquid

Specific details on test material used for the study:

Name of test material (as cited in study report): Isopropanol

Test animals

Species:

rat

Strain:

Sherman

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing:Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum):Not reported
- Acclimation period:Not reported


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):Not reported


IN-LIFE DATES: Not reported

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No information provided

Doses:

Not reported. The authors state rats are given dosages differeing in a ratio of 10.

No. of animals per sex per dose:

6 rats/dose group

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days (or other?); Not reported
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Not reported
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not reported

Statistics:

Not reported

Results and discussion

Preliminary study:

NA

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5 840 mg/kg bw

Based on:

not specified

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The oral LD50 value of isopropanol in rats exceeds 2000 mg/kg body weight.
Isopropanol does not have to be classified and has no obligatory labelling requirement for acute oral toxicity according to the:
- Globally Harmonised System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007)
- Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures.