Registration Dossier
Registration Dossier
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EC number: 913-660-8 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: HYDROWIN by EPISUITE
- Version / remarks:
- calculation model
- Principles of method if other than guideline:
- estimated by calculation (EpiSuite v4.11, HYDROWIN v2.00)
- GLP compliance:
- no
- Transformation products:
- not measured
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 100 yr
- Remarks on result:
- other:
- Remarks:
- According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
- Conclusions:
- According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
- Executive summary:
A study was conducted to determine the hydrolysis properties on N-[3-(dimethylamino)propyl]stearamide, one of the main constituent of the substance.
According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: HYDROWIN by EPISUITE
- Version / remarks:
- calculation method
- Principles of method if other than guideline:
- estimated by calculation (EpiSuite v4.11, HYDROWIN v2.00)
- GLP compliance:
- no
- Transformation products:
- not measured
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 100 yr
- Remarks on result:
- not measured/tested
- Remarks:
- According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
- Conclusions:
- According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
- Executive summary:
A study was conducted to determine the hydrolysis properties on N-[3-(dimethylamino)propyl]docosanamide, one of the main constituent of the substance. According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
Referenceopen allclose all
Description of key information
A study was conducted to determine the hydrolysis properties on N-[3-(dimethylamino)propyl]stearamide and
N-[3-(dimethylamino)propyl]docosamide the two main constituents of the substance.
According to Episuite v4.11, HYDROWIN v2.00 "most amides hydrolyze to acids extremely slowly at 25 degC and pH7 with half-lives measured in centuries".
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 100 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
