Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-123-2 | CAS number: 1746-03-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992-01-14 to 1992-02-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Vinylphosphonic acid
- EC Number:
- 217-123-2
- EC Name:
- Vinylphosphonic acid
- Cas Number:
- 1746-03-8
- Molecular formula:
- C2H5O3P
- IUPAC Name:
- vinylphosphonic acid
- Test material form:
- other: Liquid: Clear colourless
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: T 16/91
- Expiration date of the lot/batch: July 1992
- Purity test date: 1992-05-13
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: in the dark
- Stability under test conditions: stable
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Age at study initiation: about 3-5 months
- Weight at study initiation: 2700-3600 g
- Housing: single
- Diet: Altromin 2123 Haltungsdiat - Kaninchen, Altromin-GmbH (Lage/Lippe, Germany), ad libitum
- Water: deionized, chlorinated water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18+/- 3
- Humidity (%): 55+/- 20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg
- Concentration: ca. 90 %
VEHICLE
- Amount applied: 0,05 mL NaCl (0,9 %) - Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- Observations were caried out 30-60 min and 24, 48, 72 h, 7 days and 14 days after removal of the test substance.
- Number of animals:
- 3 animals (3 min exposure)
1 animal (4 hours exposure) - Details on study design:
- TEST SITE
- Area of exposure: dorsal, about 2.5 x 2.5 cm
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing: rinsing with tap water
- Time after start of exposure: 3 min or 4 h
OBSERVATION TIME POINTS
30-60min, 24 h, 48 h, 72 h, 7 days, 14 days
SCORING SYSTEM:
Erythema and edema were scored according to a 5 graded scale.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4 hours exposure
- Basis:
- animal #1
- Remarks:
- only one animal tested
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within:
- Remarks:
- 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 4 hours exposure
- Basis:
- animal #1
- Remarks:
- only one animal tested
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of skin irritation were noticed after an exposure period of 3 minutes.
The animal exposed for 4 hours exhibited moderate to severe erythema at the observation time points 30-60 min, 24, 48, 72 h (score 3, respectively). At the observation time points 7 and 14 days the erythema were scored 4 (severe). Therefore, the findings were considered not reversible.
Edema were scored 3, 2, 1 and 1 at the time points 30-60 min, 24 h, 48 h and 72 hours and 1 after 7 and 14 days. - Other effects:
- - Other adverse local effects: The skin appeared discoloured/white after 4 hours exposure. Further effects observed throughout the observation period: encrustation, scaled and dry skin.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The test material was shown to be corrosive to skin after an exposure period of 4 hours.
- Executive summary:
The test material was examined for its potential to cause skin irritation/corrosion in New Zealand White rabbits. 500 mg were diluted with 0.05 mL 0.9 % NaCl and applied under semiocclusive dressing. Three animals were exposed for 3 minutes, one animal was exposed for 4 hours. After removal of the patches the test sites were washed with tap water. Skin findings were scored 30-60 min, 24 h, 48 h, 72 h and 7 and 14 days after removal. No skin findings were noted in the animals exposed for 3 minutes. Signs of moderate to severe irritation were observed in the animal exposed for 4 hours. These findings were not reversible within the 14 days-observation period. Therefore the test item was concluded to be corrosive to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
