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EC number: 439-750-2
CAS number: 183487-56-1
the results of the 24 -hour reading were taken into consideration and in
this case the test article at 75% and 50% resulted in 3 scores of 1. No
skin reactions were observed in the other concentrations. Therefore, the
most representative concentration to stimulate a state of immune
hypersensitivity was 75% in bidistilled water used in the induction
phase. The highest non-irritating concentration is determined as the
concentration which induces responses in the four guinea pigs no more
severe than two grades of +/- and two of 0. Therefore, the highest
non-irritating concentration for the challenge was determined as the
concentration of 25% in bidistilled water.
irritant reaction was observed on and after the sixth induction
application in relation with the repetitive topical application of the
test article at 75% on the same skin site. From the sicth induction
application to the eigth application, one or two animals were observed
with slight confluent erythema and three or four animals with patchy
erythema. In the last induction twelve animals were also observed with
slight confluent erythema.
no skin effect was noted after the challenge procedure
-there were no deaths during the course of the treatment period
-no symptoms of systemic toxicity were observed in the animals
-the body weight of the animals was within the range commonly recorded
for animals of this strain and age.
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